Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



Analyses of chemical composition and gastroprotective and antinociceptive properties of Eugenia involucrate DC. leaves

Giovana Vechi; Adriana Campos; Roseane Leandra da Rosa; Karla Capistrano; Tailyn Zermiani; Fatima de Campos Buzzi; Sergio Faloni de Andrade; Valdir Cechinel Filho.

Abstract
Eugenia genus has shown relevant therapeutic results as a medicinal plant, and that is why this study aimed to know the chemical composition of E. involucrata leaves and its gastroprotective and antinociceptive potential. The leaves were collected at two moments, January and July of 2014. Leaves were macerated in methanol, resulting in Crude Methanol Extracts (CME), denominated CME-jan and CME-jul. The extracts were partitioned with chloroform and ethyl acetate. Phytochemical analysis was performed by conventional chromatographic techniques and the isolated substances were analyzed by usual spectrometric techniques. The major substance isolated from the ethyl acetate fraction was (-)-catechin and phytol from the chloroform fraction. Gastroprotective evaluation was performed by the ulcer model induced by ethanol, and the extract reduced significantly the total damaged area and the area of injury relative to the treatments with doses of 125 and 250 mg/kg, but the 125 mg/kg dose was more effective. In the evaluation of the antinociceptive activity, the model of writhes induced by acetic acid was used, and both extract and fractions reduced nociception (26.5 to 64.4% at 10 mg/kg). Chloroform fraction collected at July had more effect (DI50 of 2.33 mg/kg).

Key words: antinociceptive activity;Eugenia involucrata;catechin;gastroprotection;phytol



Share this Article


Advertisement
Applied Medical Research

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons