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Original Article

J App Pharm Sci. 2018; 8(7): 100-107

Mild Permanent Chronic Thyroid Hormones Insufficiency Induces Cognitive Dysfunction in the Adult Male and Female Rats

Mohammad Reza Afarinesh; Mahdieh Taheri; Tahereh Haghpanah; Fatemeh Nouri; Iman Znangiabadi; Mohsen Abedini Esfahlani; Khadijeh Esmailpour; Yaser Masoumi-ardakani; Fatemeh Gloshan; Vahaid Sheibani.


Objectives: Hypothyroidism is believed to result in irreversible neurological and cognitive impairments. The aim of this study was to examine cognitive functions of male and female rat offspring exposed to 6-propyl-2-thiouracil (PTU) following levothyroxine-therapy.
Materials and Methods: Wistar rats were used for the experiment. To induce chronic mild neonatal hypothyroidism in rat offspring, PTU (1.5, 3, and 6 ppm) was added to drinking water of the rat offspring from postnatal day 1 to week 12. In the separated group, levothyroxine (50mg/kg. SC) was injected in the Hypo 6 ppm. Morris water maze (MWM) and novel object recognition (NOR) tests were performed at weeks 10 and 12 respectively.
Results: : In both male and female rats, there was an increase (P

Key words: hypothyroidism;Spatial learning;Morris Water Maze;Novel object recognition;Rats

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