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Original Article

J App Pharm Sci. 2018; 8(10): 106-112

Garcinia binucao crude ethanolic leaf extract prevents alcohol-induced neurotoxic effects on learning, short-term memory, and motor functions in Drosophila melanogaster

Ourlad Alzeus G. Tantengco; Joanne Jennifer E. Tan; Nicholas Robert C. Tan; Maria Concepcion C. Sison; Paul Mark B. Medina.

Excessive alcohol consumption is associated with cognitive and behavioral impairments. Drosophila melanogaster is a commonly used model for learning and memory studies. We looked at Garcinia binucao to determine the ability of its crude ethanolic leaf extract to reduce deficits in learning, short-term memory, and motor functions due to alcohol exposure. Chronic alcohol exposure significantly decreased motor function by 22%(p

Key words: Garcinia binucao;Drosophila melanogaster;alcohol-induced neurotoxicity;learning;short-term memory;motor function

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