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Original Article

J App Pharm Sci. 2018; 8(10): 122-128


Activity of inhibit the cell cycle and induct apoptosis in HeLa cancer cell with combination of Sabrang onion (Eleutherine palmifolia (L.) Merr) and Starfruit Mistletoe (Macrosolen cochinchinensis (Lour.) Tiegh)

Roihatul Mutiah; Anik Listiyana; Arief Suryadinata; Rahmi Annisa; Abdul Hakim; Wirda Anggraini; Retno Susilowati.

Abstract
The combination of Eleutherine palmifolia (L) Merr (EP) and Macrosolen cochinchinensis (Lour.) Tiegh (MC) extracts have been proven to empirically potential for cure cancer. The aims of this research were to prove scientifically the anticancer potential of the combination of EP and MC as well as its effects on the cell cycle and the apoptosis of Hela cancer cell. The MTT method was used to measure cytotoxic effects. The effect inhibition cell cycle and induction of cell apoptosis were measured by flow cytometry method. The results showed that the combination of EP and MC give an induction of apoptosis effect of HeLa cancer cell through inhibition of cell cycle in the G0-G1, S and G2/M phases synergistically until synergist strong. Therefore, the combination of EP and MC can be recommended as a candidate drug for cancer therapy.

Key words: Eleutherine palmifolia (L) Merr;Macrosolen cochinchinensis (Lour.) Tiegh;anti-cancer;HeLa Cervical cancer cell



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