Objective: The studier in which the relationship between serum lipid profile and depression was examined had revealed controversial results. The purpose of the present study was to explore the relationship between serum lipid and lipoprotein levels and depressive disorders with atypical and melancholic features. Method: The study consisted of 39 depressive patients and 20 healthy controls. The depressive patients were divided into two groups, depressive disorders with atypical features and melancholic features. The patients were assessed by Structured Clinical Interview for DSM-IV and then, Hamilton Depression Rating Scale (HDRS) was administered to all patients. Fasting serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels were measured at 08.00-09.00 a.m. TK/HDL, LDL/HDL and body mass index (BMI) was calculated for all subjects. Result: The patient groups and control group were matched for sex, age and BMI. We did not find any statistically significant difference in serum TC, HDL, LDL, VLDL, TG levels and TK/HDL and LDL/HDL among groups (P>0.05). There was also no correlation between serum lipid and lipoprotein levels and sex in patients and control groups. Conclusion: Our results did not support the hypotheses that lipid profile was a biological marker to distunguish depressive disorder with melancholic features from atypical features, and that there may be a gender difference between lipid concentrations and major depression.
Depression, melancholic features, atypical features, cholesterol, lipoprotein