To summarize current knowledge on induction of Epithelial-Mesenchymal-Transition (EMT) during viral oncogenesis.
Publications describing âinduction of EMT in viral induced cancersâ were retrieved from Pubmed database and managed in the End Note software (version XIII) for further analysis.
Some oncogenic viruses like EBV, HPV, HBV, HCV, and adenoviruses have recently been shown to switch on the EMT-programming prior to tumor invasion. Various proteins involved in viral induced EMT include TGFß, NFkB, Smad3, Cadherins, Catenins and Hbx, amongst others.
Epithelial-Mesenchymal-Transition has been involved as metastatic tool by oncogenic viruses. We recommend further research on the topic to fill the existing gaps. (Rawal Med J 2011;36:317-321).
Oncogenic viruses, EMT, tumor invasion, metastasis.