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In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity

Varsha Sharma, R. C. Agrawal.

Objective: This study aimed to evaluate the antioxidant and hepatoprotective potential of Glycyrrhiza glabra hydromethanolic root extract against carbon tetra chloride (CCl4) induced oxidative-stress mediated hepatotoxicity in liver tissue of Swiss albino mice.
Background: Medicinal plants play a vital role for the development of new drugs. Glycyrrhiza glabra is a widely used medicinal plant. It has many phyto-constituents and active components, which can be used for many diseases.
Methods: For the antioxidant and hepatoprotective study, measurement of GSH, CAT, LPO bio-markers in Liver tissue of Swiss albino mice were taken. The animals were divided in six different groups each having 4 mice. The requisite dose of CCl4 was dissolved in appropriate solvent (1.5ml/kg body wt) and administrated as single i.p. dose per mice after 6 hr of last treatment of extract to the animals in each group. Mice were received orally administration of extract up to 7 days. Positive Control group received single i.p. injection of 1.5ml/kg body wt CCl4 in 0.9% saline.
Results: The results suggest that, the crude extract of root of G. glabra at the doses of 300 and 600mg/kg body wt. expressed significant hepatoprotective potential against CCl4 induced oxidative stress mediated hepatotoxicity in student t test (p

Key words: Antioxidant, CCl4, Catalase, Glutathione, Glycyrrhiza glabra, Hepatotoxicity, Intraperitoneal, Liver, Oxidative stress

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