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IJCRR. 2014; 6(1): 69-71


DIAGNOSTIC SIGNIFICANCE OF ADA (ADENOSINE DEAMINASE) IN TUBERCULOUS PLEURAL EFFUSION

Kalpana K. Dave, Nikunj V. Mehta, R.N. Gonsai, Dimple J. Dangia.

Abstract
Introduction: Adenosine deaminase (ADA) is a useful biochemical parameter for tuberculous pleural effusion. Studies have confirmed diagnostic role of Adenosine deaminase for early diagnosis of pleural tuberculosis in high prevalence countries like India.
Objective: To assess the diagnostic level of ADA in tubercular pleural effusion and to determine its Sensitivity, Specificity, Positive and Negative predictive value.
Material and Methods: The Retrospective study was carried out on 51 patients suffering from pleural effusion in B.J.M.C. Ahmedabad during May to Aug-2012. Detailed clinical history, physical examination and routine investigation of all patients including ADA estimation by Galanti And Giusti method was done.
Results : ADA level in tuberculous pleural effusion ranged from 25-160 U/L with a mean level of 72 U/L and at >60 U/L the Sensitivity-69.2%, Specificity-92%, Positive Predictive Value-90% and Negative Predictive Value -74%. So this was best cut off point for ADA level to confirm diagnosis.
Conclusion: ADA was found positive with a mean value of 72 U/L in tuberculous pleural effusion with 69.2% sensitivity and 92% specificity at cut off value of 60 U/L.

Key words: Adenosine deaminase, Tuberculousis, Pleural effusion.



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