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JARMS. 2013; 5(4): 380-385


PREVALENCE OF METALLO Β-LACTAMASE PRODUCING P.AERUGINOSA IN CLINICAL ISOLATES AND ITS ANTIBIOGRAM

*Panwar Sonu, Singh R. P., Sabharwal Ravjit Kaur, Gupta Nikunj, Bhatt Hitesh, Kumar Dinesh, Singh Sukhpreet, Singh Parduman, Goel Varun.

Abstract
Pseudomonas is one of the common pathogen associated with nosocomial infections. It is known to cause variety of infections and is tolerant to antiseptics . It exihibits intrinsic resistance to several antibiotics.1 Many strains of Pseudomonas are showing resistance not only to all generations of Cephalosporins, Quinolones and Aminoglycoside but also to Carbapenems which are commonly used in tertiary care hospitals to treat infections . Apart from ESBLs it produces Carbapenemases which is capable of hydrolysing most β lactams including Carbapenems . These enzymes are thought to have evolved from penicillin binding proteins.2 Present study was conducted with an objective to find out the presence of MBL producing P. aeruginosa in Multidrug resistant strains and formulate antibiotic policy to treat patients effectively. This study was conducted in microbiology department of MR medical college Gulbarga during Jan 2010 to December 2010 from patients admitted to the hospital.126 isolates of Pseudomonas aeruginosa were obtained from various clinical specimens.Prevalence of Metalloβ lactamase production and their antibiogram were analyzed to know the alternative drugs which can be used to treat infections with these strains.

Key words: MBL- Metalloβlactamase, CDM- Combined disc method, DDST- Double disk diffusion method



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