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JARMS. 2013; 5(4): 392-395


EVALUATION OF CLINICAL USE OF FLUOROQUINOLONES+ NITROIMIDAZOLES COMBINATION AS EMPIRIC TREATMENT IN ELDERLY ACUTE DIARRHEAL PATIENTS

*Navin Budania, Bhardwaj Vinod, Saharan Savita, Sharma Priyamvada, Kumar Amit, Goyal Ankur.

Abstract
This study was carried out in S.N. Medical College, Agra and private hospitals and clinics near S.N. Medical College to analyze the usefulness of fluoroquinolones + nitroimidazoles combination as empirical therapy for acute diarrhea in Elderly patients. Diarrhea is an important cause of morbidity and mortality in elderly. Diarrhoea is one condition where antibacterial are often over-prescribed. Fixed-dose combinations (FDCs) of an antiprotozoal and an antibacterial, for the treatment of diarrhea, have been available in the Indian pharmaceutical market for about a decade.1 FDCs of quinolones and nitroimidazoles have not been recommended in any standard books, but continue to be heavily prescribed drugs in acute diarrhea of Elderly patients; there are no studies available to justify this combination. The study was carried out in elderly patients, age 60 years or above, who were prescribed fluoroquinolones + nitroimidazoles combination as empirical therapy for acute diarrhea. A total of 127 Prescription of patients were collected and analyzed, out of which 80 patients who had prescribed fluoroquinolones + nitroimidazoles combination as empirical therapy were selected for the study. Selected patient's prescriptions were analyzed and there Stool samples were examined. Out of 80 selected patients 47 (59%) were found non infective in etiology and only 33 (41%) patients Stool samples were positive, in which parasitic infection was the commonest cause 18 (22%) followed by bacterial 15 (19%) and there was no case of mixed infection (Parasitic + Bacterial). Combining fluoroquinolone (antibacterial) with nitroimidazole (antiamoebic) is highly irrational for treatment as elderly acute diarrheal patients because patient suffers only from one type of infection and most cases of acute diarrhea are non infective.

Key words: fluoroquinolones + nitroimidazoles combination, Elderly, acute diarrhea



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