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Effect of green tea extract and epigallocatechin-3-gallate potency on lipid profile and coronary artery morphology of dyslipidemic rats

Wahyu Widowati, Hana Ratnawati, Roro Wahyudianingsih, Yelliantty Yelliantty, Maesaroh Maesaroh, Dwiyati Pujimulyani, Tjandrawati Mozef.

Abstract
Objective: Dyslipidemia is a major risk factor in atherosclerosis and cardiovascular disease. Green tea and catechins have anti-dyslipidemic potency. This research was carried out to evaluate the effects of green tea extract (GTE) and epigallocatechin-3-gallate (EGCG) on lipid profile, antioxidant activities and histopathology of coronary artery in dyslipidemic rats.
Methods: Six weeks old male Sprague-Dawley rats were fed high cholesterol diet for 2 month. Three groups were treated with green tea extract (450, 300 and 150 mg/kg body weight/daily), another 3 groups were treated with EGCG (15, 10 and 5 mg/kg BW/daily), and a final group remained as untreated positive control. The treatment duration was 21 and 42 days. Lipid profile including total cholesterol (TC), triglyceride (TG), low and high density lipoprotein (LDL-HDL) levels, superoxide dismutase (SOD) activity, malondialdehyde (MDA) and coronary artery histophatology were evaluated. Data was analyzed using ANOVA and Duncan post hoc test.
Results: GTE and EGCG decreased TC, TG, LDL and MDA, and increased HDL, SOD levels significantly in both 21 and 42 days treatment groups. Furthermore, GTE and EGCG improved the coronary arteries histology.
Conclusion: GTE and EGCG improved lipid profile and coronary arteries histological structure in dyslipidemic rats.

Key words: Antioxidant; Coronary artery; Dyslipidemia; Green tea; Lipid profile



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