Background: Sulfonylureas were among the first oral antihyperglycemic agents developed, but patients on a sulfonylureas experience hypoglycemia. Severe hypoglycemia was a potentially life-threatening condition. Objective: The aim of the study was to compare the frequency of hypoglycemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide. Material &Methods: Total 50 patients were included in the study. These patients were divided in group I & II. Group I (n=25): Patients were given Tab. Glibenclamide. Group II (n=25): Patients were given Tab. Glimepiride for 24 weeks. Results: Patients with glibenclamide experienced hypoglycemia (12%) and weight gain (4%) as the main adverse effects while patients with glimepiride had no such adverse effects. Conclusion: In people with type 2 diabetes, glimepiride was associated with fewer episodes of hypoglycemia than glibenclamide.
Type 2 diabetes mellitus, glimepiride, glibenclamide, hypoglycemia, sulfonylureas.