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In vitro modulation of pancreatic insulin secretion, extrapancreatic insulin action and peptide glycation by Curcuma longa aqueous extracts

Violet Kasabri, Peter R. Flatt, Yasser H. A. Abdel-Wahab.

Abstract
Objective: Medicinal, edible and aromatic plants have been used as folk remedies in traditional treatments worldwide. This study investigates the antidiabetic efficacy and action mode of Curcuma longa Linn. (Zingiberaceae).
Methods: Effects of aqueous extracts (AEs) of C.longa on insulin secretion and action were studied using the insulin-secreting BRIN-BD11 and the adipocyte-like 3T3-L1 cell lines, respectively. In vitro models were employed to evaluate effects on starch digestion using alpha-amylase/amyloglucosidase and protein glycation.
Results: C.longa AEs stimulated basal insulin output and potentiated glucose-stimulated insulin secretion concentration-dependently in the clonal pancreatic beta cell line, BRIN-BD11 (P

Key words: Curcuma longa Linn. (Zingiberaceae), insulin action, insulin secretion, peptide glycation, starch digestion



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