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Archives Medical Review Journal. 2014; 23(3): 367-386

Pediatric Intracerebral Tumors

Ersin Hacıyakupoğlu, Kadir Oktay, Semih Kıvanç Olguner, Mustafa Emre Saraç, Derviş Mansuri Yılmaz, Sebahattin Hacıyakupoğlu.

Histopathology, appearance, biological behaviour, cytogenesis, molecular biology, physiology and effects on the brain development of the pediatric intracerebral tumors are completely different from the tumours in adults. In adults, glioblastoma multiforme and meningiomas are seen mostly, but in children pilocytic astrocytoma, medulloblastoma and germ cell tumours are more common. When pediatric intracerebral tumours are detected, families should be supported and the physcosocial trauma affecting the family should be reduced. As pediatric intracranial tumours are located mostly in the midline, neurological symptoms of them are quite faint. As cerebrospinal fluid paths are obstructed, increased intracranial pressure symptoms appear. Special anesthetic and surgical techniques should be performed for children. Stereotactic surgery, neuroendoscopy, functional and intraoperative magnetic resonance imaging and neuromonitoring could be used. Radiotherapy (in patients aged 3 and more years old), stereotactic radiosurgery, chemotherapy and gene therapies could be performed as the other treatment modalities.

Key words: Pediatric intracerebral tumors, Stereotactic radiosurgery, Alpha-phetoprotein, Human chorionic gonadotropin, Radiotherapy, Chemotherapy

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