Objectives: To investigate the frequency of complications in patients with acute Organo-Phosphorus (OP) poisoning.
Methodology: This cross-sectional study was conducted at the National Poison Control Center (NPCC), Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan from May 2012 to August 2012. A total of 100 patients with acute OP-poisoning were included in the study. Hemoglobin (Hb) levels, white blood cell (WBC) count, platelet count, chest-crepts, muscle-fasciculations, score on Glasgow comma scale, serum cholinesterase levels, mortality rates and causes of mortality were recorded.
Results: Of 100 patients, 69 were females and 31 were males with female/male ratio 2:1. The most frequently affected age group was 21-30 years in both genders and the most frequent reason for poisoning was an attempted suicide (98%). 50% patients had serum cholinesterase levels below normal values. 81% patients had Hb levels of 10mg/dl or less. Out of 100 patients, 21(60%) patients died because of sudden respiratory failure, 9 (25%) due to cardiac arrest, 2 (5.7%) due to septic shock and 3 (8.5%) due to CNS depression. 54 patients recovered and discharged on follow up & 11 left against medical advice (LAMA). The mortality rate was 35%.
Conclusion: OP-poisoning, in addition to several other complications, caused respiratory failure, anemia and thrombocytopenia in most of the young patients admitted with suicidal intention using OP compounds.
Organophosphorus (OP) poisoning, OP poisoning complications, respiratory failure, thrombocytopenia.