Zizyphus lotus L. is a common medicinal plant used in Moroccan folk medicine to treat many gastrointestinal disorders such as ulcers and diarrhea. In this paper, we aim to evaluate the anti-ulcer properties of Z. lotus (fruits) methanol extract (ZLM) in various experimental models, as well as to evaluate its anti-Helicobacter pylori and anti-scavenging properties. Anti-ulcer studies were performed in three ulcerogenic induced models (HCl/EtOH, pylorus ligature and Aspirin) in Wistar rats. Up to 500 mg/kg body weight, ZLM produced a non-significant inhibition in the acute ulcer induced by HCl/EtOH solution and a significant effect on the aspirin model (46.2 %). The anti-ulcer effect was lower, for both models, compared to cimetidine and omeprazole used as positive controls. ZLM showed a significant reduction of gastric juice secretion and total acidity and an increase in pH value in pylorus-ligature model similarly to positive controls. ZLM inhibited, at 128 µg/ml, three H. pylori clinical strains among which two were resistant to both metronidazole and clarythromycine. ZLM showed a moderate scavenging capacity in DPPH assay (IC50= 477.6 ± 47.6 µg/ml). ZLM extract act essentially as antacid agent, which support the use of this plant in the traditional Moroccan medicine to cure gastrointestinal disorders.
Moroccan folk medicine, Zizyphus lotus (L.), antioxidant potential, gastric ulcer, Helicobacter pylori.