The present case-control study includes 50 patients with multiple sclerosis, diagnosed according to McDonald criteria, 35 women and 15 men, median age 40.8 years (21-61). Twenty of them had familial history with disease transmitted from the mother. Relapsing-remitting course was noted in 42 of them, relapsing-progressive in 4 and secondary progressive in 4. Statistically significant association with multiple sclerosis was found only for the highest serum levels of EBVCA IgG > 750 U/ml (17 vs. 8, p 1.000 U/ml (23 vs. 3, p750 U/ml ΠΈ EBVNA > 1.000 U/ml, the entire cohort and controls.
In contrast to the literature, we found no convincing evidence for the role of EBV in MS. Except a true association, the highest serum levels may reflect a synergistic influence of other genetic or enviromental factors or may be just a secondary phenomenon.
However, the possible role of EBV at the early stages of MS pathogenesis could not be excluded and future and larger studies with a proper design are justified.
multiple sclerosis, EBV, HLA-G 14bp ins/del.