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Imatinib resistance in chronic myelogenous leukemia: an emerging challenge

Aparna Khandelwal, Mallika Kawatra, Virendra Bhandari, Prashant S. Yeshwante.

Abstract
Resistance to imatinib is a significant clinical issue, and the underlying mechanism of this resistance is multifactorial. The efficacy of imatinib in chronic myeloid leukemia (CML) in achieving a high remission rate and improving prognosis has seriously been challenged by the development of mutants of BCR-ABL gene, which resist the action of imatinib, which is a tyrosine kinase inhibitor. We present here a case of a 35-year-old male, a known case of CML on imatinib therapy, the patient eventually landed in blast crisis and succumbed to the disease and secondary infections.

Key words: Chronic myeloid leukemia, Imatinib resistance, blast crisis



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