Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

23

J App Pharm Sci. 2014; 4(7): 129-136


Simple Spectrophotometric and HPTLC-Densitometric Methods for Determination of Cefdinir in Bulk Powder and Pharmaceuticals, and in Presence of its Hydrolytic Degradation Products

Omar Abdel-Aziz, Maha Farouk, Reham Nagi, Laila Abdel-Fattah.

Abstract
The present work describes development and validation of four different stability indicating methods for quantitative analysis of cefdinir (CFD) in bulk powder and pharmaceuticals, and in the presence of its acid and alkaline induced hydrolytic degradation products. The first method is based on derivative spectrophotometry. First derivative spectrophotometry was applied where CFD was determined at 313.4 nm in the presence of its alkaline degradation product and also second derivative spectrophotometry where CFD was determined at 298.2 nm in the presence of its acid degradation product. The second method is based on the first derivative of ratio spectrophotometry of CFD at 312 nm in the presence of its acid degradation product and at 310.2 nm in the presence of its alkaline degradation product. The third method is based on the mean centering of ratio spectrophotometry where the drug was determined at 288.4 and 284.8nm in laboratory prepared mixtures with its acid and alkaline degradation products, respectively. The fourth method is HPTLC-densitometry using diethylether-methanol-water-glacial acetic acid (6: 3: 1: 0.05, v/v) as a developing system. Due to simplicity, rapidity and accuracy of the proposed stability indicating methods, they are effective for quality control analysis.

Key words: Cefdinir; Derivative; Ratio spectra; Mean centering; HPTLC; Stability.



Share this Article


Advertisement
Progress in Orthopedic Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons