Organophosphorus pesticides are used widely for agriculture, vector control, and domestic purposes. Despite the apparent benefits of these uses acute organophosphorus pesticide poisoning is an increasing worldwide problem, particularly in rural areas. Their toxicity has been recognised since the 1930s, when they were also developed for use as chemical warfare agents. Our aim is to provide an evidence based review of the pathophysiology, diagnosis and management of acute organophosphorus pesticide poisoning. We emphasize that in future, especially in developing countries, Government authorities should be encouraged to control organophosphate product licensing, manufacture, storage, import, methods of use and delivery, food contamination and disposal.
Atropine, Organophosphorus poisoning, Pesticide, pralidoxime