Objectives: The present study was aimed at assessing histological changes on the cerebellum following low- and high-dosage oral administration of potassium bromate to adult wistar rats.
Methods: Twenty healthy adult wistar rats weighing 180-200g were used for the study. They were fed with feed and water during an acclimatization period of two weeks before administration of potassium bromate began. They were divided into four groups: A, B C and D. Group A served as control while rats in groups B, C and D received 50, 100 and 150mg per kg body weight of potassium bromate respectively. Administration lasted for 21 days and body weight was recorded weekly. At the end of administration, they were sacrificed by chloroform inhalation method, and the cerebellum was harvested and processed for examination.
Results: The control group showed normal weight gain as well as normal physical activity. Group D showed unsteadiness in movement, difficulty in breathing, and two rats died after the 18th day of administration. Rats in group C experienced difficulty in breathing and slight unsteadiness in movement. Group B were mildly affected. Histopathological examination of groups C and D showed degenerative changes and haemorrhage in the cerebellum.
Conclusion: The present study showed that potassium bromate had harmful effects on the cerebellum in a dose-dependent manner, and its use should be discouraged.
Potassium bromate, cerebellum, toxicity, lethal dose.