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Characterization of Methicillin Resistant Staphylococcus aureus from various clinical samples at tertiary care hospital of rural Gujarat

Nirav Pandya, Anil Chaudhary, Sanjay Mehta, Rosy Parmar.

Cited by (2)

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is an established pathogen in most health care
facilities. MRSA strains are also important for their resistance to many other commonly used antibiotics.
Objectives: To find out prevalence of MRSA strains and coproduction of β-lactamase and antibiotic sensitivity
pattern of these strains.
Materials and Methods: During the period of September 2009 to December 2010, a total of 200 strains of S. aureus
were isolated from various specimens of different patients attending and admitted at C. U. Shah Medical College and
Hospital, Surendranagar, Gujarat. Standard procedures were followed for isolation and identification of S. aureus
isolates. Antibiotic susceptibility testing and detection of MRSA was done by Kirby Bauer disk diffusion method, as
per Clinical and Laboratory Standards Institute (CLSI) guidelines. The production of β-lactamase was studied by the
rapid method using nitrocefin disk.
Results: Among 200 isolates of S. aureus, 117 (58.5 %) were methicillin-resistant, of which 110 (94.02%) were found
to be multidrug-resistant. Among 117 MRSA strains, 86.59 % were resistant to ciprofloxacin, 81.71% were resistant
to cephalexin, 80.49% were resistant to cefaclor and 79.27% were resistant to erythromycin. Vancomycin was the
most effective drug as all MRSA isolates were sensitive to it. 93.90% MRSA isolates were sensitive to linezolid and
91.46% were sensitive to teicoplanin. 82.91% MRSA isolates were also co-producers of β-lactamase.
Conclusions: The high incidence of MRSA in this hospital warrants for the judicial use of antibiotics and application
of infection control measures to avoid therapeutic crisis resulting from multidrug-resistant MRSA.

Key words: MRSA, Staph aureus, Rural Gujarat

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