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Pharmacological study of the effect of curcumin, diclofenac sodium alone and in combination against hepatotoxicity-induced experimentally in rats.

Hekma A. Abd El Latif, Sawsan S. Mahmoud, Gihan F. Asaad, Marwa El-Hussiny.

Abstract
AIM: Liver disease is usually a profound life-changing disease as the liver functions affects almost every other organ system in the body. In the present study the hepatoprotective effect of curcumin, diclofenac sodium alone or in combination against liver injury with CCl4 and ischemia/reperfusion (I/R) model was studied.
METHODS: The effect of curcumin and diclofenac sodium in doses of 200 mg/kg body weight (bw) and 5 mg/kg bw respectively against liver toxicity induced by CCl4 (1ml/kg bw) in olive oil [1:1 (v/v)] every other day for 8 weeks and by hepatic ischemia/reperfusion in adult male albino rats was studied. Different antioxidant and liver function parameters as well as histopathological findings were reported to find the protective effect of both curcumin and diclofenac sodium against hepatotoxicity. Statistical analysis was carried out by using one way ANOVA followed by Student Newman Keuls multiple comparisons test.
RESULT: It was showed that curcumin protected against CCl4-induced hepatotoxicity as well as ischemia/reperfusion induced liver injury. On the other hand, diclofenac sodium caused deleterious effects especially in presence of CCl4 where high mortality rate was observed. In addition, administration of curcumin and diclofenac sodium concurrently with CCl4 did not show any significant improvement in animals.
CONCLUSION: The hepatoprotective effect of curcumin is due to its antioxidant potential. Diclofenac sodium markedly synergized the hepatotoxic effect of CCl4. Curcumin could be used safely to protect the liver against various insults. Further clinical trials are needed to prove this claim.

Key words: Curcumin, diclofenac sodium, CCl4, ischemia/reperfusion, hepatotoxicity



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