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Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning.

Cited by (2)

Abstract
Background: One of the primary causes of obesity-associated disease is the habitual consumption of a high-fat, high-calorie diet. The purpose of this study was to determine the effect of consumption of a high-fat, high-calorie breakfast on consecutive days on the area under the curve (AUC) for 22 emerging cardiovascular disease (CVD) biomarkers in young women (N=8). Material and Methods: Subjects consumed a high-fat (70% of daily calories, 100% of daily fat) breakfast meal on two consecutive days. Blood samples were collected pre-meal, 1h, 2h, 3h, 4h, and 5h post-meal. Cholesterol, triglycerides, and glucose were measured using an enzymatic assay. CVD biomarkers were analyzed simultaneously in serum using a multiplex method and AUC was calculated separately for each biomarker on each day. A paired t-test with significance set at P

Key words: Inflammation, Nutrition, Meal-Response, Multiplex, Post-Prandial



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