A 54-year-old female presented with a large mass associated with pain at left popliteal region with fungating surface ulceration on skin. Patient was known case of localized (sporadic) neurofibroma at the same site operated 4 years back. Histopathological examination revealed a Malignant Peripheral Nerve Sheath Tumor (MPNST) of high grade nature. We report this case for its clinical behavior, large size, recurrence and histopathological features.
Malignant Peripheral Nerve Sheath Tumor, Soft tissue sarcoma, Popliteal fossa.