Aim: Together with low intake, malabsorbtion is the most important factor causing vitamin B 12 (vit B 12) deficiency. Vitamin B 12 deficiency also has been shown to be associated with Helicobacter pylori (HP) gastritis in some studies. Aim of this study is to investigate the frequency of HP gastritis in patients with vit B 12 deficiency.
Patients and methods: 24 patients (mean age: 15.6 ± 1.3 years ) have been included the study. Serum vit B12 level has been measured by electrochemiluminescence immunoassay method. Upper GIS endoscopy and rapid urease test have been performed to all patients and biopsy specimens also have been investigated for HP histopathologically.
Results: While 15 (62.5%) of patients have been presented with neurological symptoms, 6 (25.0%) of them have been presented with fatigue and weakness. 3 (12.5 %) of patients have been detected while searching for other reasons. Vit B 12 levels of patients were not statistically different in these three groups (p=0.224). 18 (75%) of patients were positive for HP. Serum vit B 12 levels of HP positive and negative patients were 108.6 ± 31.1 pg/mL and 113.5 ± 41.2 pg/mL respectively (p=973).
Conclusion: Although vitamin B 12 levels of HP positive patients were lower than that of HP negative patients this differance was not statistically significant. Hereafter new studies with high number of patients will be helpful to investigate relation between HP infection and vitamin B 12 deficiency.
Vitamin B 12, Helicobacter pylori, child