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The role of serum magnesium level in type 2 diabetes mellitus

N. Surendra Naik, Shashikala Lamani, Shashidhar S. Devarmani.

Background: Diabetes mellitus is one of the most common metabolic disorder and leading cause of death and disability in the world. The incidence of diabetes is increasing globally and in India. Magnesium depletion has a negative impact on glucose homeostasis and insulin sensitivity in patients with type 2 diabetes. Hypomagnesaemia can lead to development of complications in diabetes. Hence there is need for the study to explore the status of magnesium in type 2 diabetes. Objectives: To estimate and compare the serum magnesium levels in type 2 diabetes patients with age/sex matched non diabetic controls.
Methods: A case control study was done in randomly chosen 100 type 2 diabetic patients and 100 non diabetic age/sex matched controls. Estimation of serum magnesium was done by enzymatic end point method.
Results: 37% of diabetic patients had low serum magnesium levels (Mg2+ level ≤1.5 mg/dL) and 9 % of controls had low serum magnesium levels. The mean serum magnesium levels were 1.96 0.54 mg/dL and 2.375 0.449 mg/dL in diabetics and controls respectively (P value

Key words: Diabetes mellitus, Magnesium, Hypomagnesaemia, Enzymatic end point method

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Journal of Molecular Pathophysiology


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