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Gulhane Med J. 2012; 54(1): 29-34

Time-dependent variations in plasma D-dimer levels and biochemical parameters in acute mesenteric ischemia: an experimental study

Yılmaz Yiğit, İbrahim Yetim, Akın Aydoğan, Orhan Veli Özkan, Ahmet Koç, Zafer Yönden.

Acute mesenteric ischemia is a pathology leading to acute abdomen with a very poor prognosis when there is a delay in diagnosis. In this study we aimed to investigate the importance of D-dimer levels and biochemical parameters in early diagnosis of acute mesentheric ischemia by assessing time-dependent variations of these parameters. Forty Wistar-Albino male rats were divided into four groups. Only laparotomy and mesenteric arterial dissection were made in the control group. In the other groups laparotomy was performed, and ischemia was constituted for 2, 4 and 6 hours by ligating mesenteric artery. Blood samples were taken for measuring serum levels of D-dimer and biochemical parameters in rats. Intestinal tissue samples were obtained from ileum to assess the level of ischemia in histopathological examination. There were significant differences between the control and 2-, 4- and 6-hour ischemia groups regarding D-dimer levels and biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, lactic dehydrogenase, creatine phosphokinase and phosphate (p0.05). D-dimer levels and biochemical parameters increased in correlation with the duration of ischemia, and there were significant differences between the groups (p

Key words: Acute mesenteric ischemia, biochemical parameters, D-dimer, early diagnosis

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