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Case Report

BTDMJB. 2015; 11(1): 36-39


Acute isoniazid intoxication: case report

Dilek Altun, Halil Çetingök, Gülay Aşık Eren, Zafer Çukurova, Oya Hergünsel.

Abstract
Isoniazid is a bactericidal antituberculosis drug, used commonly for treatment and prophylaxis of tuberculosis. Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis with a high anion gap resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma. Pyridoxine, in a dose equivalent to the amount of isoniasid ingested, is the only effective antidote. Here, we reported a 14 years old female patient with the diagnosis of isoniasid intoxcication, successfully treated in our intensive care unit.

Key words: Isoniasid intoxication, seizures, metabolic acidosis



Article Language: Turkish English



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