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Med J Bakirkoy. 2015; 11(1): 36-39

Acute isoniazid intoxication: case report

Dilek Altun, Halil Çetingök, Gülay Aşık Eren, Zafer Çukurova, Oya Hergünsel.

Isoniazid is a bactericidal antituberculosis drug, used commonly for treatment and prophylaxis of tuberculosis. Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis with a high anion gap resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma. Pyridoxine, in a dose equivalent to the amount of isoniasid ingested, is the only effective antidote. Here, we reported a 14 years old female patient with the diagnosis of isoniasid intoxcication, successfully treated in our intensive care unit.

Key words: Isoniasid intoxication, seizures, metabolic acidosis

Akut izoniazid intoksikasyonu: Olgu sunumu

İzoniazid tüberküloz tedavisi ve proflaksisinde kullanılan bakterisidal etkili bir antitüberküloz ilaçtır. Akut izoniazid zehirlenmesi sodyum bikarbonat tedavisine dirençli yüksek anyon açıklı metabolik asidoz, ölüme neden olabilen ve standart antikonvülsanlara dirençli nöbetler ve koma tiriadı ile karakterizedir. Alınan izoniazid miktarına eşit dozda piridoksin bilinen tek etkin antidottur. Bu yazıda, izoniazid zehirlenmesi tanısıyla yoğun bakım ünitemizde başarı ile tedavi edilen 14 yaşında bir kadın olgu sunulmuştur.

Anahtar Kelimeler: İzoniazid zehirlenmesi, konvülsiyon, metabolik asidoz

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