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Gulhane Med J. 2015; 57(2): 91-97

The Investigation of Neuroprotective Effects of Aminoguanidin and N-Acetylcystein administration alone and combination in Spinal Cord Trauma model

Özkan Tehli, Nail Çağlar Temiz, Mehmet İlker Özer, Halil İbrahim Seçer, Engin Gönül, Serhat Pusat, Alparslan Kırık, Mehmet Kadri Daneyemez.

In this study the neuroprotective efficacy of N-Acetylcystein and Aminoguanidin administered after spinal cord injury was examined regarding clinical and laboratory outcome. Rats were divided into 5 groups: Control group, trauma group, Aminoguanidin group, N-Acetylcystein group, and Aminoguanidin+N-Acetylcystein group. Total laminectomy of thoracal 9th or 10th vertebra was performed on all rats. Spinal trauma was formed by weight drop model for all groups except the control group. 1 ml of %0.9 NaCl solution was administered twice daily to control group. 100mg/kg Aminoguanidin and N-Acetlysistein was given twice daily for 5 days to own group, Both drugs were administered to Aminoguanidin+N-Acetylcystein group in the same dose.Neurologic examination results were graded according to Tarlov’s chart and all the rats were clinically assesed by Rivlin and Tator’s inclined plane degrees. Treumatized spinal cord segments were obtained. Malondialdehyte, superoxidedismutase, glutathion peroxidase activity of these tissue specimens were measured. Results revealed an increase in the inclined plane degrees and neurological examination grading along with statistically significant decrease in Malondialdehyte level, superoxidedismutase and glutathion peroxidase activities in Aminoguanidin, N-Acetylcystein and Aminoguanidin+N-Acetylcystein groups as compared to control group. We propose, Aminoguanidin and N-Acetylcystein can show neuroprotection when used in combination or alone but there is no additive effect of combined use.

Key words: Aminoguanidin, N-Acetylcystein, spinal cord trauma

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