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IJHSR. 2015; 5(4): 65-72

Prevalence of Hepatitis E Virus among Hemodialysis Patients: One Egyptian Center Study.

Maysaa El Sayed Zaki, Mostafa Abdelsalam, Nahla Hamed Anbar, Basem Salama El-deek.

Background: In Egypt Hepatitis E virus (HEV) is considered as an endemic infection.
The aim of the present study was to determine the prevalence of HEV infection among HD patients and to study the risk factors associated with such infection.
Methods: The study included ninety six cohort HD patients in Mansoura University Hospital, Egypt in addition to one hundred sixty seven healthy blood donors. Full virological markers assay for hepatitis B, C and E viruses were performed. Positive samples for serological markers for hepatitis E were subjected to nested PCR for HEV.
Results: HCV IgG was the predominant serological markers among HD (42.7%) followed by HEV IgG (22.9%). Serological virological markers for HCV and HEV were significantly higher in HD patients compared to healthy blood donors (18.6%-5.9%, P=0. 0001, P=0. 02 respectively). HEV viremia was detected in statistically significantly higher percent of HD patients (36.4%) compared to blood donors (20%), P=0. 07.
The duration of dialysis and the number of blood transfusion units had no statistically significant association with HEV viremia. HCV antibodies were prevalent among 50% of patients with HEV viremia.
Conclusion: From this study we can reason that HEV is common infection among hemodialysis patients. Further studies are obliged to clear up the wellspring of HEV disease in dialysis units in Egypt.

Key words: Hemodialysis, HEV, PCR

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