Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1



Insulin resistance in sub clinical hypothyroidism

Shyam Rameshwar Adhau, Sunita Girish, Gaurav Shashikant Kansara.

Abstract
Background: Insulin resistance (IR) is an established risk factor for cardiovascular diseases. It is an underlying phenomenon in pathogenesis of type 2 Diabetes mellitus. Recent literature proves the development of insulin resistance in Overt hypothyroidism (OH), but there is controversy as to whether this association is also present in sub clinical hypothyroidism (SCH).
Aims: Present study was designed to explore the presence IR in SCH.
Settings & design: The study included 60 hypothyroidism patients and 30 age and sex matched euthyroid controls. Hypothyroidism patients were grouped as SCH (n=30) and OH (n=30).
Methods: We examined total cholesterol levels, fasting blood glucose, fasting serum insulin levels and Insulin resistance (calculated by using HOMA-IR software).
Statistical analysis: All statistical data was analysed by ANOVA using the Graph Pad Prism software, Version 5.01.
Results: HOMA-IR values showed highly significant association between controls and SCH. TSH levels were positively correlated with insulin and HOMA IR in patients with SCH.
Conclusions: Therefore, it will be good practice to screen people &Type 2 DM patients for presence of SCH, so that early detection and prompt intervention can prevent or prolong the appearance of various fatal complications associated with IR & help in managing diabetes holistically.

Key words: Insulin resistance, Subclinical Hypothyroidism, HOMA-IR



Share this Article


Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons