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Egypt. J. Exp. Biol. (Bot.). 2011; 7(2): 197-202


ANTIMICROBIAL ACTIVITY OF CALLUS EXTRACTS DERIVED FROM CHAMOMILLA RECUTITA L. SEEDLINGS AND THEIR ROLE IN CURING INDUCED SKIN WOUND INFECTIONS IN MICE

Enass Hussein Ali Ibrahim K. Mohammad Ismail M. Chaloob.

Abstract
This paper investigates the antimicrobial activity of Chamomilla recutita L. callus culture ethanol extract and its ability to cure induced skin wound infections in mice. Callus was initiated on Murashige and Skoog (MS) medium containing some combinations of BA and 2,4-D concentrations. Results indicated that 1 mg/l of Benzyl adenine (BA) combined with 0.1 mg/l of 2,4-Dichlorophenoxyacetic acid (2,4-D) initiated the highest callus of the plant. Ethanol callus extract exhibited antimicrobial activity against the studied microorganisms at the concentrations 20 and 40 mg/ml. Callus ethanol extract at the concentration 40 mg/ml was effective in the treatment of induced skin mice injury infected with Staphylococcus aureus. Callus ethanol extract was compared with the commonly used drug for skin infections (Cefotaxim sodium). A mixture of ethanol callus extract and Cefotaxime sodium at a percentage of 50% was the most effective treatment against St. aureus. Azulene and apigenin were estimated in the callus extract was suggested to be the main reason for callus extract cure of wound infections in mice.

Key words: Chamomilla recutita L. ethanol callus extract; antimicrobial activity, drugs, mice skin infection



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