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IJCRR. 2015; 7(8): 63-66


CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL PROFILE OF MAMMARY PAGET DISEASE

Salma Bhat, Rohi Wani, Samina Khanday, Sheema Sheikh, Ruby Reshi, Humaira Bashir.

Abstract
Mammary Paget disease (MPD) is a rare manifestation of the nipple-areola complex that is often associated with an underlying
in situ or invasive carcinoma. MPD is very often hormone receptor negative. However, unlike ER and PR, Her 2 neu receptor
is overexpressed in the vast majority of Mammary paget disease. In this study we have evaluated the clinicopathological and
immunohistochemical aspects of this disease. In this retrospective study, all cases of mammary Paget disease referred to the
Department of pathology, Government Medical College Srinagar from 2006 till 2013 were evaluated. Collective data were analysed
by descriptive statistical analysis methods.There were 19 cases of Mammary paget disease reported from 2006 to 2013.
All but one of the MPD cases were associated with an underlying ductal carcinoma .The underlying breast malignancy was high
grade with a significant proportion having axillary nodal involvement. One patient had underlying DCIS. On IHC , only two cases
of MPD were ER and PR positive. There was a single triple negative MPD case. Conversely Her2 neu was strongly positive in
sixteen cases of MPD .The same immunohistochemical spectrum was shared by underlying breast carcinoma including DCIS.
MPD is often associated with extensive underlying malignancy which is of high grade and is frequently Her2 neu positive with a
resulting poor prognosis. Therefore for patients with clinical suspicion of MPD breast examination, mammography and even
biopsy are highly recommended.

Key words: Mammary Paget disease, Ductal carcinoma, Her2 neu



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