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Effect of glycemic status on peripheral nerve conduction in lower limbs in type 2 diabetes mellitus patients

Pranali P. Sonawane, Swati H. Shah, Savita M. Vaidya, Pradeep S. Nahar, Anupam S. Khare, Kiran H. Buge.

Abstract
Background: Diabetes mellitus (DM) is one of the most common chronic diseases globally. Diabetic neuropathy is the most common & troublesome complication. But exact pathogenesis is not yet known. Comparatively there are few studies showing relation between glycemic status & diabetic neuropathy. Hence present study was conducted, which was aimed to assess the same in lower limbs in type 2 DM.
Methods: 60 type 2 diabetes mellitus male patients were selected from diabetic OPD. 30 were having glycated hemoglobin (HbA1c) 6%-9% (group B), 30 were having HbA1c > 9% (group C). They were compared with age and sex matched 30 normal healthy controls (group A). Conduction velocity and amplitude of bilateral sural sensory nerve action potential (SNAP) and peroneal compound muscle action potential (CMAP) were recorded. Glycated hemoglobin was measured using ion exchange resin method.
Results: Group B and group C had significantly lesser means of conduction velocity and amplitude of sural
SNAP (p

Key words: Type 2 diabetes mellitus, Diabetic neuropathy, Nerve conduction study, HbA1c



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