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Preclinical evaluation of Boswellia serrata for anxiolytic activity

Prabhakar Adake, Mahalaxmi S. Petimani, M. Jayaraj, S. N. Rao.

Abstract
Background: Boswellia serrata (BS) has been described in the ancient Ayurvedic texts Sushruta Samhita and Charaka Samhita. It possesses anti-inflammatory, analgesic, anti-arthritic and antioxidant properties. It is found that BS helps in surging of GABA levels in mice brain. The aim of this study was to evaluate the possible anxiolytic activity of BS in Swiss albino mice by light and dark arena (LDA) and elevated plus maze (EPM) models.
Methods: In this study, BS (50 mg/kg, 100 mg/kg and 200 mg/kg; p.o) was evaluated for anxiolytic action and compared with standard drug (diazepam) and control (normal saline) in mice by LDA and EPM models. In LDA, number of entries and time spent in light and dark boxes were noted for individual mouse. Similarly, number of entries and time spent in open and closed arms were recorded for EPM model.
Results: One-way Analysis of Variance (ANOVA) followed by Dunnett’s post-hoc test was used to analyze the data. BS in a dose of 50 mg/kg has shown significant increase in time spent in light box (p

Key words: Anxiolytic activity, Boswellia serrata, Elevated plus maze, Light and dark arena



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