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Egypt. J. Exp. Biol. (Bot.). 2010; 6(2): 177-182


THE IN VITRO EVALUATION OF ANTIBACTERIAL AGENTíS ACTIVITY AGAINST URINARY TRACT INFECTIONS ISOLATES

Mohamed Samhan Ahmed Badri.

Abstract
Activity of ten different antibacterial agents commonly used in treatment of urinary tract infections (UTI) at AL-Batnan Medical Centre, Tobruq-Libya was studied against 8 different bacterial species isolated from 718 UTI patients, during 2004 - 2008. The study of the antibacterial sensitivity / resistance pattern indicated that UTI caused by (E. coli , Klebsiella pneumoniae, Staphyloccus epidermidis ,Staphyloccus aureus , Proteus mirabilis) isolates showed relatively a high to moderate rate of sensitivity to ciprofloxacin (77.6%) , amoxicillin (67.7%), nitrofurantoin (65.9%) and ceftrixone (58.5%). While Enterococcus faecalis isolates showed sensitivity to amoxicillin (70.2%), naldixic acid (60.3%) with a low rate of sensitivity to ampicillin (9.2%). The drug of choice to the Pseudomonas aeruginosa isolates was ciprofloxacin which revealed (87.5% sensitivity), while the other antibacterial agents failed completely or succeeded with low percentage in inhibition of Pseudomonas aeruginosa isolates growth. The study also revealed a noticeable increase in UTIs between 2004 and 2008 with a high rate of infections in children and females, with a prevalence of E. coli as a most common causative agent of UTI.

Key words: Antibacterial agents, sensitivity tests, urinary tract infections isolates



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