Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

0

Egypt. J. Exp. Biol. (Zoo.). 2014; 10(1): 41-46


IMMUNOMEDULATORY EFFECTS OF SINGLE AND COMBINATORIAL ANTI-CANCER CHEMOTHERAPY IN A TUMOR MOUSE MODEL

Mohamed L. Salem Shaimaa Talat Ahmed El-Barbary.

Abstract
Anticancer chemotherapy is a successful treatment of tumor to kill or to low the multiplying rate of tumor cells. Although the immunomodulatory effect of single chemotherapy has been investigated, the effects of combinatorial chemotherapy are ill defined. Therefore the aim of this study was to evaluate effects of CTX and CIS alone or in combination as conventional chemotherapeutic drugs on the total and differential numbers of leukocytes. Groups of adult female Swiss albino (CD1) mice were treated with intraperitoneal (i.p.) injection of 0.5 x 106 cells/mouse of Ehrlichs ascites carcinoma (EAC) cells. After one day of injection, mice were i.p. treated either with PBS, (10 g/mouse) CIS, (4 mg/mouse) CTX or in combination with different sequential treatment protocol, mice were bled on day11 and complete blood count (CBC) was assessed. Treatment with low dose of (10 g/mouse) CIS or with high dose of (4 mg/mouse) CTX followed by (10 g/mouse) CIS induced slight decreases in the total numbers of white blood cells (WBCs) and absolute numbers of neutrophils and lymphocytes. Treatment with high dose (4 mg/mouse) of CTX or with low dose of (10 g/mouse) CIS followed by CTX (4mg/mouse) induced marked decreases in the total numbers of WBCs, relative and absolute numbers of neutrophils and lymphocytes. The data suggested that certain sequential treatment protocol of high dose of chemotherapy can induce lower lymphopenia, which have important implications in cancer treatment.

Key words: Chemotherapy, Cyclophosphamide, Cisplatin, Ehrlich carcinoma, White blood cells, lymphocytes, neutrophils



Share this Article


Advertisement
Journal of Molecular Pathophysiology

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons