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Egypt. J. Exp. Biol. (Zoo.). 2013; 9(2): 173-180


NIGELLA SATIVA OIL AS A PROTECTIVE AGENT FOR CISPLATIN MEDIATED HEPATOTOXICITY IN RATS

Abdel-Kader M. Abdel-Kader Maha A. El-Demellawy Eatemad A. Awadalla Al-Hassan M. Mustafa.

Abstract
Cisplatin (cis-diamminedichloroplatinum II), a platinum-based drug, is one of the most frequently used anti-neoplastic agents for various types of cancer. Cisplatin (CP) like other chemotherapeutics causes excessive reactive oxygen species (ROS) generation and also induces a decrease in plasma antioxidant levels, which may reflect a failure of the antioxidant defence mechanism against oxidative damage. In the present study, the protective potential of Nigella sativa (NS) oil against cisplatin-induced hepatotoxicity in rats was evaluated. Liver tissue samples were collected at 7, 15, and 21 days. Total protein, malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels were determined at each interval. Also, DNA fragmentation and histological examination were performed. The obtained data showed that CP treatment-induced an increase in MDA levels and DNA fragmentation, a decrease in the activities of GSH, SOD, and the total protein and considerable histopathological damage. While Nigella sativa oil pre-treatment showed restoration of the normality of the hepatic tissues. In conclusion, these results suggested that NS oil supplementation protects against CP-induced hepatotoxicity.

Key words: Cisplatin, Nigella sativa oil, Liver, Hepatotoxicity, Rats



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