Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1

Egypt. J. Exp. Biol. (Zoo.). 2009; 5(0): 263-271


EFFECT OF HYPERCHOLESTEROLEMIA AND ISOSORBIDE DINITRATE ADMINISTRATION ON SERUM NITRIC OXIDE AND SOME RELATED BIOCHEMICAL PARAMETERS IN MALE ALBINO RATS

Aziza AM. El-Shafey, Mohamed N. Seddeik, Moshira ME. Seliem, Magda M. El-Azabi, Marwa AE. Abd El-Maksoud.

Abstract
Isosorbide dinitrate "ISDN" is an organic nitrate that generates nitric oxide "NO" that helps in treatment of the vascular disturbance which results from metabolic hypercholesterolemia. Forty two adult male albino rats weighting 170-190 g were divided randomly into six groups, each of seven rats, as follows: control group (standard diet), coconut oil treated group (0.5 ml daily), cholesterol treated group (400 mg/kg BW dissolved in 0.5 ml coconut oil), ISDN treated group (1.0 mg/kg BW dissolved in 0.5 ml H2O), ISDN plus cholesterol treated group (ISDN + cholesterol) for 3 weeks and cholesterol followed with ISDN treated group (cholesterol for 3 weeks then ISDN for 3 weeks) by oral administration. Serum nitric oxide, antioxidant enzymes "superoxide dismutase (SOD) and glutathione peroxidase (GPx)" activities, lipid profile, glucose, uric acid, total protein, albumin and globulin percentage were determined. At the end of the experimental period, coconut oil treated group showed a significant increase in serum of both high density lipoprotein "HDL" and very low density lipoprotein "VLDL" and a significant decrease in serum SOD activity as compared to the control group. Cholesterol treated group showed a significant increase in total cholesterol "TC" and low density lipoprotein "LDL-C" and a significant decrease in NO level, SOD and GPx activity as compared to the control one. ISDN administration showed a significant increase in the triglyceride "TG", VLDL, and NO levels, but exhibited a significant decrease in LDL, albumin and GPx activity compared to control group. The ISDN plus cholesterol group showed a significant increase in LDL-C level and a significant decrease in albumin and GPx activity compared to the control one. The group treated with cholesterol followed with ISDN showed significant increase and decrease in HDL level and SOD activity, respectively compared to the control group. ISDN administration after cholesterol induction helped in the return of most studied parameters to the control values.

Key words: Hypercholesterolemia, Isosorbide dinirate and Nitric oxide



Share this Article


Advertisement
American Journal of Research in Medical Sciences

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons