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Med J Bakirkoy. 2016; 12(2): 76-82


Is serum tenascin-C level potential biomarker in pancreatic adenocarcinoma?

Senem Karabulut, Mehmet Karabulut, Halil Alış, Makbule Tambaş, Selin Kapan, Osman Köneş, Şule Karaman, Murat Serilmez, Faruk Taş.

Abstract
Objective: Tenascin-C (TNC) is an extracellular matrix protein involved in the tissue construction. Its expression levels have been detected low levels in normal tissues, but high in many tumors. In this study, we aimed to determine the clinical significance of serum TNC levels in patients with pancreatic adenocarcinoma (PA).
Materials and Methods: Thirty-three patients with histopathologically confirmed PA diagnosis and sex- and age-matched 30 healthy controls were included into the current study. Serum TNC levels were measured using Enzyme-Linked Immuno Sorbent Assay (ELISA) method.
Results: Median age was 59 (range, 32-84). Of the patients, 61% were male, 70% had good performance status, and 68% had tumors localized at pancreas head. Pancreaticoduodenectomy and palliative surgery were performed in 5 (15%) and 4 (12%) of the 9 (27%) patients who underwent surgical procedure. Serum TNC levels were found to be significantly higher in patients compared with control group (p0.05). Similarly, it was shown that serum TNC levels had no effect on overall survival (p=0.31).
Conclusions: Serum TNC level is a diagnostic biomarker for patients with PA. However, it has neither predictive nor prognostic value in this group of patients.

Key words: Pancreatic adenocarcinoma, Tenascin-C, diagnosis



Pankreas adenokarsinomunda serum tenascin-C düzeyi potansiyel bir biyobelirteç midir?

Özet
Amaç: Tenascin-C (TNC) doku yapılanmasında görev alan bir ekstrasellüler matriks proteinidir. Normal dokularda düşük, birçok tümörde ise yüksek düzeyde ekspresyonu tespit edilmiştir. Bu çalışmada, pankreas adenokarsinom (PA)’lı hastalarda serum TNC düzeylerinin klinik önemini belirlenmesi amaçlanmıştır.
Gereç ve Yöntem: Çalışmamıza histopatolojik olarak tanısı konfirme edilmiş 33 PA’lı hasta ile yaş-cinsiyet olarak eşleştirilmiş 30 sağlıklı kontrol alındı. Serum TNC düzeyleri, Enzyme-Linked Immuno Sorbent Assay (ELISA) yöntemiyle belirlendi.
Bulgular: Ortanca teşhis yaşı 59 (aralık, 32-84) idi. Hastaların %61’i erkek, %70’inin performans durumu iyi ve %68’inde tümör lokalizasyonu pankreas başı bölgesindeydi. Cerrahi uygulanan 9 (%27) hastanın; 5 (%15)’ine pankreatikoduodenektomi operasyonu, 4 (%12)’üne ise palyatif cerrahi uygulandı. Serum TNC düzeyleri, hasta grubunda kontrol grubuna göre anlamlı olarak yüksek bulundu (p0.05). Ek olarak, serum TNC düzeylerinin genel sağkalım üzerinde etkisinin olmadığı gösterildi (p=0.31).
Sonuçlar: Serum TNC, PA’lı hastalarda tanısal biyobelirteçtir. Fakat, prediktif ve prognostik değeri mevcut değildir.

Anahtar Kelimeler: Pankreas adenokanser, Tenascin-C, tanı



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