Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

23

Med J Bakirkoy. 2016; 12(1): 24-32


The predictive and prognostic value evaluation of serum extracellular matrix proteins levels in patients with pancreas adenocarcinoma

Senem Karabulut, Mehmet Karabulut, Halil Alış, Nergiz Dağoğlu, Makbule Tambaş, Selin Kapan, Ebru Oran, Hilal Oğuz, Faruk Taş.

Abstract
Objective: Fibronectin (FN),vitronectin (VTN), and tip IV kollagen (Kol IV) are the important components of the extracellular matrix (ECM) proteins. The objective of this study was to determine the clinical significance of serum levels of these molecules in pancreas adenocarcinoma (PA) patients.
Material and Methods: A total of 33 patients with a pathologically confirmed diagnosis of PA and age- and sex-matched 30 healthy controls were enrolled into this study. Serum FN, VTN, and Kol IV concentrations were determined by the enzyme-linked immuno-sorbent assay (ELISA) method.
Results: The median age at diagnosis was 59 years, range 32 to 84 years where 61% of the patients were male. Majority of the patients (70%) had good performance status (0-1). The most common tumor localization was head of pancreas (68%). Of the 9 patients who undergone surgical intervention, 5 patients (15%) had pancreaticoduodenectomy, while palliative surgery was performed in the remaining 4 (12%) patients. The baseline serum FN, VTN, and Kol IV levels were significantly higher in patients with PA than in the healthy control group (p=0.001, p=0.007 and p

Key words: Pancreas adenocarcinoma, fibronectin, vitronectin, Tip IV kollagen, diagnosis



Pankreas adenokanserli hastalarda serum ekstrasellüler matriks proteinlerinin prognostik ve prediktif değerinin araştırılması

Özet
Amaç: Fibronektin (FN), vitronektin (VTN) ve tip IV kolajen (Kol IV) ekstrasellüler matriks (ECM) protenleridir. Bu çalışmada pankreas adenokarsinomlu (PA) hastalarda bu moleküllerin serum düzeylerinin klinik önemini belirlemeyi amaçladık.
Gereç ve Yöntem: Çalışmamıza patolojik olarak konfirme edilen PA tanılı 33 hasta ile yaş-cinsiyet olarak eşleştirilmiş 30 sağlıklı kontrol alındı. Serum FN, VTN ve Kol IV düzeyleri, enzyme-linked immuno-sorbent assay (ELISA) yöntemiyle değerlendirildi.
Bulgular: Ortanca tanı yaşı 59 (32-84) olarak saptanan hasta grubunun %61’nin cinsiyetinin erkek olduğu görüldü. Hastaların çoğunluğunun (%70) performans durumunun iyi (0-1) olduğu belirlendi. En sık tümör lokalizasyonun pankreasın baş bölgesi (%68) olduğu saptandı. Cerrahi girişim uygulanan 9 (%27) hastanın; 5 (%15)’ine pankreatikoduodenektomi operasyonu ve 4’üne (%12) palyatif cerrahi uygulandı. Serum FN, VTN ve Kol IVdüzeyleri, hasta grubunda kontrol grubuna göre anlamlı olarak yüksek bulundu (sırasıyla; p=0.001, p=0.007 ve p

Anahtar Kelimeler: Pankreas adenokarsinomu, fibronektin, vitronectin, Tip IV kolajen, tanı



Share this Article


Advertisement
Journal of Apitherapy

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons