There are more than 125 million people with diabetes in the world. This study was
carried out on a herbal formulation Glucova for its antidiabetic activity in alloxan induced diabetic
rats. Glucova tablet and capsule had shown significant antidiabetic activity in comparison to the
standard reference drug marketed with the name Glibenclamide on various parameters such as body
weight, blood glucose, serum cholesterol, serum triglyceride, serum HDL, serum VLDL, serum
LDL, serum urea, serum creatinine, serum ALPH, serum ALT, serum AST, serum bilirubin, serum
total protein and albumin. It was observed to have almost parallel values for all the biochemical
parameters estimated in comparison to reference standard drug - Glibenclamide. Furthermore, the
histopathological analysis of pancreas showed that the herbal formulations Glucova tablet and
Glucova capsule (GT and GC) retained the tissue degeneration in comparison to control group.
Diabetes, Glucova, Glibenclamide, Histopathological study, Herbal formulation.