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PROKINETIC EFFECT OF HERBOMINERAL UNANI FORMULATION (DOLABI) IN DIABETIC RATS

RAHUL SOMANI, ABU SHAIKH, DILPESH JAIN. RAJKUMAR SHETE.

Abstract
This study was undertaken to investigate the prokinetic activity of Unani herbomineral
formulation (Dolabi) in streptozotocin induced diabetic rats and its in vitro antioxidant activity. Rat
model of diabetes was established by intraperitoneal injection of streptozotocin (55 mg/kg, i.p).
Rats were divided into three groups: Normal control, diabetic control and treatment groups. After
two weeks of treatment, rats were administered with phenol red meal followed by last dose of
Dolabi and they were screened for gastric emptying (GE), intestinal transit (IT) and in vitro study
of distal colonic smooth muscle. In vitro antioxidant activity of Dolabi was assessed on the basis
of radical scavenging activity of the stable Diphenyl-2-picryl-hydrazyl (DPPH) free radical.
Percentage of GE and IT was significantly (P < 0.05) decreased in diabetic rat as compared to
normal control groups. In streptozotocin induced diabetic rats, Dolabi significantly (P < 0.05)
accelerated both GE and IT as compared to diabetic control rats. Significant (P

Key words: Dolabi, Unani medicine, Herbal medicine, Diabetes, Oxidative stress, Medicinal plants, Diabetic neuropathy.



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