Hepatotoxicity with halothane inhalation has been studied extensively. Risk factors include obesity, female sex, a history of drug allergies, and multiple exposures to anesthetic agents. Anesthetic agents including halothane, enflurane, isoflurane, and desflurane can produce metabolic hepatocellular injury in humans to a variable extent. Sevoflurane is expected to be less hepatotoxic than halothane because it is metabolized less, and the main metabolite is different and rapidly glucuronated. Cross-sensitization between halothane and other volatile agents has been previously reported with isoflurane, enflurane, and desflurane. In this article, the topic of postoperative hepatic dysfunction associated with new inhalation agents is revisited.
Hepatotoxicity, inhalation agents