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Is Further Examination Necessary in Patients with Behçet's Disease Without Any Neurological Signs or Symptoms?

Halit YAŞAR, Mehmet Güney ŞENOL, Semih ALAY, Yalçın ÖNEM, Emine Ece BOYLU, Rıfat Erdem TOGROL, hAKAN TEKELİ, Mehmet SARAÇOĞLU.

Background and Purpose: A mean percentage of 5% was reported for neurological involvement in researches related to Behçet's disease. The neurological involvement may be characterized by headache, neuropsychiatric symptoms, brain stem involvement, cerebral venous thrombosis or peripheral nervous system involvement. Sometimes neurological involvement may be seen without any neurological sign or symptom. In our study, we aimed to evaluate the cognitive, psychiatric and neurophysiological responses in Behçet's disease without neurological sign and symptom.
Methods: The study was performed on patients with Behçet's disease without neurological signs and symptoms and healthy volunteers that would make the control group. The patients were assessed with Mini Mental State Examination, Hamilton Rating Scale for Depression, nerve conduction study and visually evoked potential.
Results: A total of 27 male patients (age: 24.88±5.45 years) were enrolled in the study. Neurological examinations of all the patients were normal. Mean Mini Mental State Examination score of the patients was 29.62±0.79 (2 patients had loss of focus, 2 patients had disturbance in the copying function) and 2 patients had mild depression in Hamilton Rating Scale for Depression. In the nerve conduction study, 2 patients had right sensory-motor carpal tunnel syndrome, 1 patient had right sensory-motor carpal tunnel syndrome - bilateral ulnar nerve entrapment. In the visually evoked potential examination, 8 patients had prolonged P100 latency, decreased amplitude and disturbance of wave morphology.
Conclusion: Visually evoked potential examination may be used as a conductive method to detect the subclinical neurological pathologies in Behçet's disease. The possible silent neurological involvement should be evaluated with further neuro-screening methods.

Key words: Behçet's disease, neurological involvement, visually evoked potential (VEP), cognitive, depression, nerve conduction study (NCS)

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