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J Res Med Den Sci. 2015; 3(2): 148-151

Bacteriological profiles of septicaemia in neonates at tertiary care hospital, Gujarat, India

Hitesh J Assudani, Jigar K Gusani, Sanjay J Mehta, Harihar H Agravat, Krupali Kothari.

Background: Neonatal septicaemia describes any systemic bacterial infection in neonates documented by positive blood culture. It is an important cause of morbidity and mortality among neonates. Neonatal sepsis may be classified according to the time of onset of the disease, < 72 hours as early-onset neonatal sepsis (EONS) and >72 hours as late-onset neonatal sepsis (LONS). EONS are caused by organisms prevalent in the maternal genital tract and LONS are caused by environmental factors.

Objectives: To identify the prevalence of septicaemia in neonates along with age and gender wise distribution, common associated factors and clinical signs/symptoms.

Material and Methods: Venous blood was collected aseptically and inoculated in blood culture bottle. Further isolation and identification was done by Standard Microbiological Guidelines. ESBL was detected according to CLSI guidelines.

Results: In present study out of 116 clinically suspected neonatal septicaemia cases, 89 (76.72%) were males and 27 (23.28%) were females. In present study out of 116 cases of neonatal septicaemia, 65 (56.03%) were early onset neonatal septicaemia and 51 (43.97%) were late onset septicaemia. Out of 89 male patients studied, in 31 (34.83%) cases pathogen were isolated. Out of 27 (23.28%) female patients studied, in 10 (37.04%) cases pathogens were isolated. In present study most common was Klebsiella spp. 39.02 %.

Conclusion: Prevalence of septicaemia is 35.34% in neonates in present study. Prevalence was higher in males. And most common associated factor was preterm.

Key words: Neonatal septicaemia, Causative bacterial pathogens, Predisposing factors

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