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Study of prognostic factors affecting outcome of urosepsis in a tertiary care hospital in Mumbai

Jayant L. Pednekar, Swapnil Shinde, Sangeeta Pednekar.

Background: Urosepsis implies clinically evident severe infection of the urinary tract and/or the male genital tract (e.g. prostate) with features consistent with systemic inflammatory response syndrome. This research was aimed at studying various prognostic factors of urosepsis and its outcome.
Methods: We prospectively observed patients admitted at Lokmanya Tilak Municipal General Hospital (LTMGH), Mumbai with a confirmed diagnosis of urosepsis from January 1, 2014 to December 31, 2014. After collecting socio-demographic data, patients were worked up with blood culture, urine routine and culture and other relevant clinical data. Data were analyzed in SPSS statistical software (SPSS v20 Inc, Chicago, USA).
Results: 100 patients were included in the final of which 51 were males and 43 were aged 40-60 years. 49 patients had diabetes mellitus, 24 had a history of urethral procedures. 39% of the patients had E.coli and 40% of the patients reported no organisms. Additionally, 50% of the patients reported shock as a complication. Presence of pus cells in urine showed statistically significant association with mortality, duration of hospital stay and residual renal impairment.
Conclusions: Urosepsis is much prevalent but rarely studied disease. Various clinical and microbiological parameters of the patient are of prognostic value and can predict the clinical outcome.

Key words: Kidney, Urospesis, Prognosis, Clinical outcome

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American Journal of Physiology, Biochemistry and Pharmacology


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