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Adv Lab Med Int. 2012; 2(3): 87-95

Association of levels of HbA1C with triglycerides/ high density lipoprotein ration - an indicator of low density lipoprotein particle size in type 2 diabetes mellitus

Niranjan Gopal, Arun Mitra S, Srinivasan A R, Muthurangan G, Saha S, Ramesh Ramasamy.

Quantitative estimation of serum Low Density Lipoprotein Cholesterol (LDL-C) is not the solitary indicator, as the size of LDL-C plays an important role, in the assessment of risk for developing vascular complications in Type 2 Diabetes Mellitus (T2 DM). The small dense LDL-C penetrates the vascular endothelium more easily and accelerates the atherosclerotic process. Direct quantitation of LDL-C particle size is not routinely possible and hence an alternative, reliable, indirect & a feasible marker of LDL-C particle size measured as TAG / HDL ratio acquires practical significance. Newly diagnosed cases of T2 DM were included for this study. Patients with Type 1 DM, Gestational diabetes and other specific causes of Diabetes were excluded from this study. Patients with known micro and macro vascular complications were excluded. Fasting Plasma Glucose (FPG), HbA1c and serum lipids were estimated and the lipid ratios were computed. FPG, HbA1c, TAG, VLDL-C, Lipid ratios (TAG/HDL, Total Cholesterol/HDL, LDL/HDL) were significantly elevated in cases (p

Key words: Key words: Type 2 Diabetes mellitus, Low Density Lipoprotein, High Density Lipoprotein, Triacylglycerol, TAG/HDL-C ratio.

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