Gel formulation provides better application property and stability in comparison to cream and ointment. Topical medication administration is a localized drug delivery system anywhere in the body by means of ophthalmic, rectal, vaginal and skin as topical routes. Skin is one of the universal and readily accessible organs of human body for topical administration and is main route of topical drug delivery system. Topical application of gels offers potential advantages of delivering the drug directly to the site of action and acting for an extended period. Topical formulations have the advantage of specific site delivery. However, drugs must overcome to the skin due to its role as a physical and chemical barrier against the penetration of chemicals and microorganisms. This barrier must be modified to allow the permeation of drugs at a suitable rate to the desired site of activity. Permeation enhancers can intercalate the skin outer layers causing structure disruption, opening favourable route for the drug to diffuse through.
Topical gel; drug delivery; permeation enhancers.